Listing includes: Movie title, Hero's character name (Actor)- The AbsentMinded Professor, Prof. Ned Brainerd (Fred MacMurray), Buy the movie
- A.I.: Artificial Intelligence, Henry Swinton (Sam Robards), Buy the movie
- Aliens, Bishop (Lance Henriksen), Buy the movie
- Alone in the Dark, Aline Cedrac (Tara Reid), Buy the movie
- Altered States, Eddie Jessup (William Hurt), Buy the movie
- The Andromeda Strain (1971), Dr. Jeremy Stone (Arthur Hill), Dr. Charles Dutton (David Wayne), Dr. Mark Hall (James Olson), Dr. Ruth Leavitt (Kate Reid), Buy the movie
- Angels & Demons, Dr. Vittoria Vetra (Ayelet Zurer)
- Armageddon, Oscar Choi (Owen Wilson), Buy the movie
- Avatar, Dr. Grace Augustine (Sigourney Weaver), Norm Spellman (Joel David Moore)
- Back to the Future (Trilogy) Dr. Emmett Brown (Christopher Lloyd), Buy the movie
- Batman Begins, Lucius Fox (Morgan Freeman) Buy the movie
- A Beautiful Mind, John Nash (Russell Crowe), Buy the movie
- Blade Runner, Dr. Eldon Tyrell (Joe Turkel), Buy the movie
- A Brief History of Time, Stephen Hawking (Himself), Buy the movie
- Bringing up Baby, Dr. David Huxley (Cary Grant), Buy the movie
- Buckaroo Banzai Across the 8th Dimension, Buckaroo Banzai (Peter Weller), Prof. Hikita (Robert Ito), Villain: Lord John Whorfin/Dr. Emilio Lizardo (John Lithgow), Buy the movie
- Chain Reaction, Dr. Lily Sinclair (Rachel Weisz), Buy the movie
- The China Syndrome, Jack Godell (Jack Lemmon), Buy the movie
- Close Encounters of the Third Kind, Project Leader (J. Patrick McNamara), Buy the movie
- Cloudy with a Chance of Meatballs, Flint Lockwood (Bill Hader, voice)
- Colossus: The Forbin Project, Dr. Charles Forbin (Eric Braedon), Buy the movie
- Contact, Eleanor Arroway (Jodie Foster), other astronomers, Buy the movie
- The Core, Dr. Josh Keyes (Aaron Eckhart), Dr. Ed Brazzleton (Delroy Lindo), Dr. Conrad Zimsky (Stanley Tucci), Buy the movie
- Dante's Peak, Harry Dalton (Pierce Brosnan), other USGS scientists, Buy the movie
- Darkman, Peyton Westlake (Liam Neeson), Buy the movie
- The Dark Knight, Lucius Fox (Morgan Freeman)
- The Day After Tomorrow, Jack Hall (Dennis Quaid), Prof. Terry Rapson (Ian Holm), other climatologists, Buy the movie
- The Day After Trinity, J. Robert Oppenheimer (himself), Buy the movie
- The Day the Earth Stood Still (1951) Klaatu (Michael Rennie). Prof. Jacob Barnhardt (Sam Jaffe).
- The Day the Earth Stood Still (2008) Klaatu (Keanu Reeves), Helen Benson (Jennifer Connelly), Dr. Grenier (Jon Ham), Dr. Barnhardt (John Cleese)
- Deep Impact, Alan Rittenhouse (James Cromwell), Buy the movie
- Destination Moon, Dr. Charles Cargraves (Warner Anderson), Buy the movie
- E.T.: The Extra-Terrestrial, Keys (Peter Coyote) Buy the movie
- Evolution, Dr. Ira Kane (David Duchovny), Harry (Orlando Jones), Dr. Allison Reed (Julianne Moore), Buy the movie
- Extraordinary Measures, Dr. Robert Stonehill (Harrison Ford)
- Fail-Safe, Prof. Groeteschele (Walter Matthau), Buy the movie
- Fantastic Four, Reed Richards (Ioan Griffud), Sue Storm (Jessica Alba). Villain Dr. Victor Von Doom (Julian McMahon), Buy the movie
- Fantastic Four: Rise of the Silver Surfer, Reed Richards (Ioan Griffud), Sue Storm (Jessica Alba). Villain: Dr. Victor Von Doom (Gideon Emery), Buy the movie
- Fat Man and Little Boy, J. Robert Oppenheimer (Dwight Schultz), other nuclear physicists, Buy the movie
- Forbidden Planet, Dr. Edward Morbius (Walter Pidgeon). Hero: Lt. 'Doc' Ostrow M.D. (Warren Stevens), Buy the movie
- The Fugitive (1993) Dr. Richard Kimble (Harrison Ford). Villain: Dr. Charles Nichols (Jeroen Krabbe
- Godzilla (1998) Dr. Niko Tatopoulos) Matthew Broderick), Buy the movie
- Goldeneye, Natalya Siminova (Izabella Scorupco), and of course in just about every Bond movie: Q (Desmond Llewelyn), Buy the movie
- Good Will Hunting, Will Hunting (Matt Damon, Prof. Gerald Lambeau (Stellan Skarsgard), Sean Maquire (Robin Williams), Buy the movie
- Gorillas in the Mist: The Story of Dian Fossey, Dian Fossey (Sigourney Weaver), Buy the movie
- Ghostbusters, Dr. Peter Venkman (Bill Murray), Dr. Raymond Stantz (Dan Akroyd), Dr. Egon Spengler (Harold Ramis), Buy the movie
- Ghostbusters 2, Dr. Peter Venkman (Bill Murray), Dr. Raymond Stantz (Dan Akroyd), Dr. Egon Spengler (Harold Ramis). Villain: Dr. Janos Poha (Peter MacNicol), Buy the Movie
- The Great Muppet Caper, Dr. Bunsen Honeydew (Dave Goelz), Buy the movie
- Hellboy, Prof. Trevor Bruttenholm (John Hurt), Buy the movie
- Hellboy II: The Golden Army, Prof. Trevor Bruttenholm (John Hurt)
- Highly Dangerous, Frances Gray (Margaret Lockwood)
- Honey, I Shrunk the Kids, Wayne Szalinski (Rick Moranis), Buy the movie
- Honey, I Blew up the Kid, Wayne Szalinski (Rick Moranis), Buy the movie
- I Am Legend, Robert Neville (Will Smith), Buy the movie
- An Inconvenient Truth, by implication, climatologists who study global warming, Buy the movie
- The Incredible Hulk (2008) Bruce Banner (Edward Norton), Dr. Elizabeth Ross (Liv Tyler), Dr. Leonard Samson (ty Burrell). Villain Dr. Samuel Sterns (Tim Blake Nelson),
- Independence Day,David Levinson (Jeff Goldblum), Dr. Brackish Okun (Brent Spiner), Buy the movie
- Indiana Jones: Raiders of the Lost Ark, Indiana Jones (Harrison Ford). Villain: Dr. Rene Belloq Buy the movie
- Indiana Jones and the Temple of Doom, Indiana Jones (Harrison Ford), Buy the movie
- Indiana Jones and the Last Crusade, Indiana Jones (Harrison Ford), Prof. Henry Jones (Sean Connery), Buy the movie
- Indiana Jones and the Kingdom of the Crystal Skull, Indiana Jones (Harrison Ford), Buy the movie
- Infinity, Richard Feynman (Matthew Broderick), Buy the movie
- The Insider, Jeffrey Wigand (Russell Crowe), Buy the movie
- The Invasion, Carol Binnell (Nicole Kidman), Villain: Dr. Henryk Belicec (Josef Sommer), Buy the movie
- Invasion of the Body Snatchers (1956) Dr. Miles Bennell (Kevin McCarthy), Dr. Dan Kauffman (Larry Gates), Buy the movie
- Invasion of the Body Snatchers, (1978), Matthew Bennell (Donald Sutherland), Buy the movie
- I.Q., Albert Einstein (Walter Matthau), Buy the movie
- I. Robot, Susan Calvin (Bridget Moynahan), Buy the movie
- Iron Man, Tony Stark (Robert Downey Jr.), Buy the movie
- Iron Man 2, Tony Stark (Robert Downey), Villain: Ivan Vanko (Mickey Rourke)
- Journey to the Center of the Earth (2008), Prof. Trevor Anderson (Brendan Fraser)), Buy the movie
- Jurassic Park, Dr. Alan Grant (Sam Neill), Dr. Ellie Sattler (Laura Dern), Dr. Ian Malcolm (Jeff Goldblum), Buy the movie
- Jurassic Park III, Alan Grant (Sam Neill), Buy the movie
- Kinsey, Alfred Kinsey (Sam Neill), Buy the movie
- Land of the Lost, Dr. Rick Marshall (Will Ferrell
- Lara Croft, Tomb Raider. Lara Croft (Angelina Jolie), Buy the movie
- Lost in Space, Prof. John Robinson (William Hurt), Dr. Maureen Robinson (Mimi Rogers), Dr. Judy Robinson (Heather Graham), Will Robinson (Jack Johnson), Buy the movie
- The Lost World: Jurassic Park, Ian Malcolm (Jeff Goldblum), Dr. Sarah Harding (Juliane Moore), Buy the movie
