Listing: Movie title, Villain's character name (Actor)
- Alien, Villain: Ash (Ian Holm), Buy the movie
- Alien: Resurrection, Villain: Dr. Mason Wren (J.E. Freeman), Dr. Jonathan Gediman (Brad Dourif), Buy the movie
- Altered States, Villain (Just misguided): Eddie Jessup (William Hurt), Buy the movie
- Batman Forever, Villain: Riddler/Dr. Edward Nygma (Jim Carey), Buy the movie
- Batman & Robin, Villain: Mr. Freeze/Dr. Victor Fries (Arnold Schwarzenegger), Buy the movie
- The Boys from Brazil, Villain: Dr. Josef Mengele (Gregory Peck), Buy the movie
- Buckaroo Banzai Across the 8th Dimension, Heroes: Buckaroo Banzai (Peter Weller), Prof. Hikita (Robert Ito), Villain: Lord John Whorfin/Dr. Emilio Lizardo (John Lithgow), Buy the movie
- A Clockwork Orange, Villain: Dr. Brodsky (Carl Duering), Buy the movie
- Dr. Jekyll & Mr. Hyde, The Strange Case of (1931) Hero/Villain: Dr. Henry L. Jekyll/Mr. Hyde (Fredric March). The first of more than a dozen movies and TV shows), Buy the movie
- Dr. No Villain: Dr. No (Joseph Wiseman), Buy the movie
- Dr. Strangelove, or: How I Learned to Stop Worrying and Love the Bomb, Villain: Dr. Strangelove (Peter Sellers), Buy the movie
- Forbidden Planet, Villain: (Really just misguided): Dr. Edward Morbius (Walter Pidgeon). Hero: Lt. 'Doc' Ostrow M.D. (Warren Stevens), Buy the movie
- Frankenstein (1994) Villain: Victor Frankenstein (Kenneth Branagh), also many, many other Frankenstein movies, Buy the movie
- The Fugitive (1993) Hero:Dr. Richard Kimble (Harrison Ford). Villain: Dr. Charles Nichols (Jeroen Krabbe
- Gattaca, Dr. Lamar, Xander Berkeley), Buy the movie
- The Incredible Hulk
(2008) Hero: Bruce Banner (Edward Norton), Dr. Elizabeth Ross (Liv Tyler),
Dr. Leonard Samson (Ty Burrell). Villain: Dr. Samuel Sterns (Tim Blake
Nelson)
- Iron Man 2, Hero: Tony Stark
(Robert Downey), Villain: Ivan Vanko (Mickey Rourke)
- Ghostbusters 2,
Heroes: Dr. Peter Venkman (Bill Murray), Dr. Raymond Stantz (Dan Akroyd), Dr.
Egon Spengler (Harold Ramis). Villain: Dr. Janos Poha (Peter MacNicol),
Buy the Movie
- Indiana Jones: Raiders of the Lost Ark, Indiana Jones (Harrison Ford). Villain: Dr. Rene Belloq Buy the movie
- The Invasion, Villain: Dr. Henryk Belicec (Josef Sommer), Heroine: Carol Binnell (Nicole Kidman), Buy the movie
- The Island, Villain: Dr. Merrick (Sean Bean), Buy the movie
- The Island of Dr. Moreau, Villain: Dr. Moreau (Marlon Brando), Buy the movie
- Silence of the Lambs, Villain: Dr. Hannibal Lecter (Anthony Hopkins)
- Spider-Man 2, Villain/Hero Doc Ock/Dr. Otto Octavius), Alfred Molina, Buy the movie
- Twister, Villain: (Not really evil, just ambitious): Dr.
Jonas Miller (Cary Elwes), Heroes: Dr. Jo Harding (Helen Hunt), Bill Harding (Bill Paxton), Dr. Melissa
Reeves (Jamie Gertz), other geophysicists, technicians, Buy the movie
